Today we’ll be diving deep into one of the most commonly used nootropics on the market. In this Aniracetam review, we’ll uncover the many uses and potential benefits of this powerful cognitive enhancer.
Can Aniracetam really improve mood, focus, memory, and learning ability? Science certainly seems to think so (and possibly more).
Read on to find out just how Aniracetam works, and what it could do for your brain power.
What is Aniracetam?
Aniracetam is an extremely potent nootropic from the racetam family, a group of compounds similar in structure and function. It was developed as an alternative to piracetam, one of the earliest synthetic nootropics .
Aniracetam was discovered in the 1970s by a Swiss pharmaceutical company by the name of Hoffman-LaRoche. It was first investigated in the 1980s as a cognitive enhancer for senile dementia sufferers, with promising results .
Since then, research has come a long way and Aniracetam has come a long way with it. Now widely used across all ages and populations, Aniracetam is one of the most commonly used nootropics available, and for good reason.
How Does Aniracetam Work?
Aniracetam works in many ways to benefit cognition through altered brain chemistry:
By regulating neurotransmitter receptors in the brain, Aniracetam use stimulates heightened neurological activity. This results in a kind of temporary “supercharging” of the cognitive system through the increased release of noradrenaline. This mechanism of action is believed to be responsible for many of its positive effects on cognitive functioning .
By binding to and counteracting the desensitization of AMPA-receptors, Aniracetam allows for a more responsive reaction to the neurotransmitter glutamate . This heightened reaction is believed to improve memory and thinking power.
Aniracetam is cholinergic, meaning that it enhances the action of the neurotransmitter acetylcholine in the brain . Acetylcholine is the primary transmitter of nerve impulses and its functionality directly affects cognitive ability.
Aniracetam ingestion seems to have a direct effect on dopamine and serotonin levels in the brain. As these neurotransmitters are mood-regulators, Aniracetam is often used in the treatment of depression, anxiety, and other mood disorders.
The benefits of Aniracetam have been extensively researched in animal studies over the last several decades. There is ample evidence to support its use as a nootropic, which we’ll run through in detail in this Aniracetam review:
Improved Memory and Learning Ability
Functional memory is a condition in which a person suffers poor memory function with no apparent physical cause. In a study done on rats, Aniracetam use reversed both functional memory and other memory impairments .
Interestingly, another study done on healthy rats showed no significant cognitive improvement . These findings suggest that Aniracetam’s efficacy as a cognitive enhancer may be greater when it comes to cognitively impaired subjects.
Suggesting otherwise was a study done on healthy human participants, which showed a significant improvement in the working memory of those in the synthetically modulated AMPA-receptor group. Visual recognition, general motor function, and general markers of intellectual functioning were all improved .
Lowered Levels of Depression and Anxiety
The efficacy of Aniracetam use to treat serious mood-disorders isn’t yet fully known, but many studies have shown promise.
One study on rats reported Aniracetam supplementation as an effective treatment for depression caused by declining brain function with age. The mechanism of action appears to be through the increased production of dopamine levels in the brain, a mood-enhancing neurotransmitter .
Another study showed an improved sociability of rats with Aniracetam supplementation, as well as a reduction in the markers of several different models of anxiety .
Though there have been no clinical trials specifically focused on the anxiety-reducing effects of Aniracetam in humans, anecdotal evidence is available in the form of users reporting dramatically reduced anxiety-levels .
In addition, a clinical study on humans (focusing on other parameters of Aniracetam use) did report enhanced mood in participants in the Aniracetam group after 6 and 12 months .
One of the most commonly reported effects of Aniracetam use is improved focus and concentration. Strangely enough, there have been no clinical trials carried out to support such anecdotal claims.
Because of Aniracetam’s proven effect on many neural pathways, it is speculated that the same mechanisms responsible for improved memory and learning function are responsible for the heightened focus reported by many users.
Recovery from Brain Damage and Dementia
Dementia is a cognitive disorder which significantly impairs the quality of life of the sufferer. Any treatments that can reduce cognitive decline are useful in its management. In one study on human patients with mild dementia, Aniracetam supplementation was reported as having a favorable effect on the preservation of many cognitive abilities .
Research to determine whether Aniracetam supplementation can have a reparative effect on damaged brain tissue is ongoing. It is thought that Aniracetam may influence rebuilding of the neural network after injury, though further studies with both animals and humans are needed to confirm this .
How To Take Aniracetam
The recommended dosage for Aniracetam is between 750 and 1,500 mg / day . It can be taken in one dose, or broken up throughout the day (500 mg x 3 etc.).
Because Aniracetam is a fat-soluble compound, it should be taken with a meal in order to increase absorption rates. Including some kind of fatty food works best. A fish-oil supplement also makes for a great combination.
Aniracetam comes in both powder and capsule form. The powder is very bitter, so we recommend mixing it with a strong-flavoured liquid.
Few studies have monitored Aniracetam use for longer than one year, so little is known about how well-tolerated use of the nootropic beyond one year may be.
Aniracetam is considered safe, and has approval from the European Medicine Agency (EMA). It is available with or without prescription. However, its use as a cognitive enhancer has not yet been approved by the FDA in the United States, though it is still readily available.
Aniracetam Side Effects
Side effects from Aniracetam use are rare. Ingestion of up to 1,500 mg per day for a year has been shown to result in no notable adverse effects in a multitude of studies.
When side effects do occur, they are generally mild but can include headache, nausea, upset stomach, and increased anxiety levels .
As Aniracetam can interact with certain other medications, care should be taking when deciding appropriate dosage .
Aniracetam can potentially enhance the effect of the co-ingested drug, which may worsen that drug’s side effects. Separating Aniracetam dosage from other medicines by a period of several hours is likely to reduce potential negative effects associated with combined ingestion.
While Aniracetam has a wide array of health benefits when taken alone, it can also be stacked with other supplements. Due care and research must be taken when combining Aniracetam with any other substance to avoid adverse effects. When done properly, stacking Aniracetam can enhance benefits from both sides:
Combining Aniracetam and Noopept – Noopept is another nootropic which affects the activity of neurotransmitters, but it works in a completely different way to Aniracetam. When stacked together, the potent effect of these nootropics on cognitive enhancement can intensify. Half doses are recommended when combining these two.
Aniracetam and CDP Choline – One of the primary mechanisms of action Aniracetam targets is increasing levels of acetylcholine in the brain. Because CDP Choline is used to increase production of Choline, a precursor of acetylcholine, taking it alongside Aniracetam can boost its effect on acetylcholine production in the brain.
Aniracetam and the racetam family – If you’ve tried out Aniracetam or a few other racetam nootropics without achieving the desired result, it might be time to combine a few of them together. Doing so can enhance cognitive effects. If combining racetams, you must be vigilant not to dose too highly; your combined stack should not exceed the recommended dose of any one of the racetams (example 1,500 mg total).
Aniracetam and natural nootropics – If you’ve been taking Aniracetam (or considering taking it) for its mood-enhancing effects, combining it with natural nootropics such as L-theanine and Baccopa Monnieri can possibly boost things further. Both of these alternative health supplements have been touted to reduce stress and anxiety levels. Mixing them with Aniracetam can have a combined effect.
My Experience With Aniracetam
As someone who has occasionally had some minor problems with brain fog (and occasionally some major problems concentrating!), I’ve experimented with a few members of the racetam family over the years.
I dosed with Aniracetam (in capsule form; as mentioned earlier on, I found the powder to be extremely bitter) for a period of six months. I took 750 mg twice a day, once with breakfast and once again with dinner. For the first three weeks, I noticed little effect (maybe a little placebo). After the three-week mark, things started to change.
The first difference I began to notice was an improvement in my general clarity. It felt as if my thoughts were lining up the way they should have been all along. I had an incredibly productive couple of months, and I enjoyed it all too. There’s nothing quite like being excited to get up and get to it.
After around the four week mark I noticed that my short-term memory was better than it had been in . . . well, recent memory (I know, I know. There’s probably a better way to phrase that. . .).
Three months in, I noticed I was in pretty consistent good humour (My SO definitely realised . . .). Whether this was a direct effect of the Aniracetam or simply related to how smoothly my work life was going I don’t know. But I was feeling good!
It’s possible that some of the benefits I experienced over the entire six months resulted from the initial increase in my productivity rather than the continued dosage. What I do know for sure: I definitely experienced some drop-off in my focus when I stopped taking Aniracetam. Maybe not down to pre-dosage levels, but there was a noticeable difference.
Where to Buy Aniracetam
HR Supplements offers Aniracetam in powder, capsule, and bundled with choline complex (see “Aniracetam Stack” section of this article for why this is a great choice). I like these guys because they offer free US shipping for decent-sized orders, and great bulk order discounts.
Prices and quantities of Aniracetam from HR Supplements are as follows:
Powder form – 30 grams for $16.99, or 60 grams for $29.99.
Capsule form – 120 count (1,000 mg per serve) for $19.99.
Aniracetam and choline complex bundle – 120 capsules of each for $35.99
The folk at https://science.bio/ are a great choice for anyone wanting to order Aniracetam that has been independently tested for quality and has a 100% satisfaction guarantee. They also offer worldwide and same-day shipping, if you’re in a hurry to get your brain moving!
Aniracetam is available in powder form from https://science.bio/. You can pick up 50g for as little as $13.99.
That’s a wrap. We hope you’ve enjoyed our Aniracetam review. Now you can make an informed decision about one of the most hyped nootropics on the market! As cognitive enhancers go, it’s hard to think of a better option.
With many proven benefits and few reported side effects, starting with a low dose of Aniracetam and seeing what it can do for you might just be a no-brainer. And if you’ve been feeling like one yourself lately, it could be worth the investment!