Coluracetam Review – The Japanese Wonder Drug!

In this Coluracetam review, we will explore this nootropic, learn how it works, how to take it, and what its potential benefits are. It is a rather new addition to the racetam class of nootropics.

Coluracetam is a drug that is believed to have a positive impact in treating mental disorders like anxiety and depression. In addition to this, it can also improve one’s memory and even vision.

What is Coluracetam

Coluracetam is also known as BCI-540 or MKC-231. It is a fat-soluble nootropic first developed as a treatment for Alzheimer’s disease in Japan back in the 1990s. It was later discovered it not only treats Alzheimer’s disease, but also has great impact on other mental illnesses, like depression and anxiety.

Coluracetam also enhances one’s memory and improves vision.

Even though it was used as a treatment for Alzheimer’s, it is important to note that none of the research related to the study has ever been published for the general population to view. [1]

Mitsubishi Tanabe Pharma Corporation synthesized it in Japan as a potential treatment for Alzheimer’s; the clinical trials for the drug were rather dissatisfying, and it was then licensed to BrainCells Inc which is a US-based biotechnology firm. The firm is known to specialize in developing drug treatments for diseases like Major Depressive Disorder, Treatment-resistant Depression, and Alzheimer’s.

The initial testing for the drug showed promising results and it was said that Coluracetam would be worth the wait. However, in 2014 the development and research were halted as BrainCells Inc closed down that year. [2]

In structure, Coluracetam is corresponding to Piracetam. Like every other racetam nootropic in the family, Coluracetam, at its core has a pyrrolidone nucleus. The newest research in this area strongly indicates for it to be a treatment for optical and retinal nerve damage and depressive disorders.

How Does Coluracetam Work

Coluracetam works as a choline enhancer in nerve cells, mainly through the choline uptake system. [3] The drug works by increasing neurotransmitter acetylcholine levels in the brain. Some researchers also state Coluracetam increases the level of choline and therefore can also restore the choline uptake system fully after nerve damage; however, this theory is yet to be confirmed in human or animal trials.

One of the reasons why Coluracetam could be the drug of the future is because of its association with acetylcholine. Acetylcholine is a type of neurotransmitter that is closely associated with cognitive functioning and memory in the brain. It is because of this association that Coluracetam’s enhancement of memory and general cognitive functioning is believed to work. [4] Coluracetam, unlike other racetam nootropics, is very potent and requires a small dosage to work. It works fast, increasing plasma levels significantly within 30 minutes of ingestion. However, levels start to decline in just 3 hours. [5]

The drug is also known to protect NDMA receptors from glutamate toxicity. When these receptors are damaged, they are known to invoke serious health problems like strokes, Alzheimer’s, and many other brain diseases.

Coluracetam is different because of the way it modulates or controls acetylcholine levels. Generally, racetams set off the production of choline by getting in contact with the appropriate receptors. However, with Coluracetam, the story changes. It uptakes the level of choline through the HACU or the high-affinity choline uptake system. This is the system that regulates the rate at which choline is extracted into neurons, which are eventually to be converted into acetylcholine.

Coluracetam increases the rate at which choline is drawn out which increases production of acetylcholine and therefore, the amount of this important neurotransmitter increases significantly. Studies also show that Coluracetam increases the choline transporter molecule CHT1 which in turn, also uptakes the production of choline.

When all these work together, it leads to an increased level of acetylcholine which is directly related to enhanced memory and cognition.

Generally, Serotonin Selective Reuptake Inhibitors or  SSRIs are the preferred method of treating mood disorders like depression or anxiety. However, SSRIs come with a long list of side effects and downsides. SSRIs also won’t necessarily work for every individual taking it, as they are not a one size fits all.

Many studies [6] report that Coluracetam is very effective in treating major depressive disorder without meddling with or disrupting serotonin levels in the brain.

Coluracetam Benefits

Research on humans is limited, and the results we have in front of us are from extensive animal testing.

However, user experiences state that many benefits come from using Coluracetam.

These benefits range from cognitive and sensory to general functioning.

The research available has shown promising results and states a range of benefits that Coluracetam can provide to its users, albeit non-human.


In an animal study in 2010, it was concluded that Coluracetam improved artificially induced memory deficiency without having any major or significant side-effects. The results were present 3 days after ingestion even though the amount imbued was negligible. [7]

Some users of Coluracetam confirm the positive effects of it by stating that not only does it improve their short-term memory but it also significantly enhanced their ability to recall, reading comprehension, and memory [8]. They also state that it had positive effects on information retention, thought process, and learning speed. [9]

Depression and Anxiety

A Phase 2, placebo-controlled study determined that the drug is effective in treating major depressive disorder and symptoms of comorbid Generalized Anxiety Disorder. This was a six-week-long study and one of the only ones involving humans.

When the test period was over, similar scores on anxiety and depression between the treatment group and the placebo group were noted.

However, it is important to recognize the fact that there was still a significant enhancement in the subset of the treatment group of people who had both MDD and GAD. [10]


According to users, Coluracetam has tremendous effects on their vision. Users state that it improves color vision, enhances shape recognition [11] [12], and improves optical vividness. This seems to be one of the most prominent benefits of using Coluracetam; however, there has been no conclusive scientific study to prove this.

How To Take Coluracetam

One can consume Coluracetam orally or sublingually. As far as dosages go, there have been almost no clinical studies on humans, so gouging an accurate dose proves to be difficult. Unlike many other medications, there is no universal dosage that one can take. However, it is suggested that the optimal dosage Coluracetam users should imbue is anywhere between 5mg-20mg, to be taken twice a day. [13]

Another thing about Coluracetam is that users may develop a tolerance for the medication rather quickly, so it is best to start with a smaller dosage.

Another recommended dosage for Coluracetam is 20mg-80mg per day which is to be taken twice (10mg in the morning and 10mg in the noon). However, many people start with a dose that is much smaller to check how they react to it.

Typically, Coluracetam is sold in powdered forms and users report that they take much smaller doses sublingually for better and faster absorption. Coluracetam is a nootropic that is fat-soluble and therefore, it is recommended that one consumes it with food containing high levels of fat, such as avocados, cheese, dark chocolate…

Coluracetam Side Effects

In this Coluracetam review, we have established Coluracetam to be a non-toxic substance, so it is generally safe to consume and is tolerable. First-time users often report feeling fatigued and exhausted after consuming Coluracetam but that is generally the result of taking too high a dosage.

In clinical trials, no significant side effects were reported in either humans or animals. The scarcity of side effects was probably one of the most notable things to come out of the studies. [14]

One of the most common side effects reported after the consumption of Coluracetam is a headache which is easy to get rid of by adding a Choline source.

Users may also complain about low mood or brain-fog. Other side effects like daytime sleepiness and nausea can easily be treated by reducing the current dosage. [15]

It is best to consume the medication after eating something that contains high levels of choline, like eggs. It is crucial to pair Coluracetam with a good choline supplement to avoid headaches.

Coluracetam Stacks

Coluracetam has many benefits but when it comes to stacking, what is the best one and what can you expect from different stacks? Each has its benefits, so let’s explore some and see what the fuss is all about.

  • Coluracetam And Oxiracetam Stack

This is a stack ideal for those who want to work on analytical problems. Perfect for those who are into programming, solving math problems, etc. This stack is good at improving cognitive function in a short time frame. 

           An ideal dose for this would be:

           750mgs of Oxiracetam

           20mgs of Coluracetam

           300mgs of Alpha-GPC

  • Coluracetam And Caffeine with L-Theanine

This is a great stack known for improving focus and learning capacity with a dash of an energy boost. One will feel calm and relaxed because of the L-Theanine, making this stack a perfect choice for fledglings.

           The dosage for this would be

           20mgs of Coluracetam

           200mgs of Caffeine

           100mgs of L-Theanine

  • Coluracetam And Phenylpiracetam Stack

This is a physically stimulating stack which will give you a great energy boost lasting for hours. However, this stack is more suitable for advanced users.


           10mgs of Coluracetam

           100mgs of Phenylpiracetam

           150mgs of Alpha-GPC

My experience with Coluracetam

My experience with Coluracetam has been nothing but positive. I started noticing a difference in my general functioning right after the first dosage. I suffer from GAD and it is generally really hard to manage. However, since I started using it to treat my symptoms of anxiety and MDD, I have noticed a positive change in my day-to-day life.

It has helped me focus, learn, and retain information in a way that is way more enhanced. Apart from improving my mood overall, it has helped in improving my sleep and provides relaxation.

Where To Buy Coluracetam

One can buy Coluracetam from and Both of these vendors provide the product at an affordable price and have some great user reviews. If you are looking to buy one yourself, these are the places to go to!


In this Coluracetam review, we’ve shown you everything this nootropic brings to the table.

Even though there is limited research about Coluracetam, its users have extensively reported that it is a great mood lifter, vision enhancer, and last but not least, potent nootropic. Coluracetam is a strong compound and therefore, even small dosages work quickly.

Coluracetam gets a big vouch from me as it has helped improve many facets of my life.

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